Synthetic rice odour blend lures gravid malaria mosquitoes

The results were published on November 30th in the journal Scientific Reports.

In sub-Saharan Africa, systematic efforts are undertaken to increase the areas under irrigated cultivation. Irrigation of crops such as rice, maize and sugarcane provides food security, but it also provides ideal larval habitats for malaria mosquitoes. This has led to the emergence of mosquito populations in inhabited areas, and an increased risk of malaria.

Irrigated crops provide mosquito larvae with shelter from various threats, as well as nutrients in the form of pollen, detritus and microorganisms. The conditions in rice paddies are particularly well suited, and can offer permanent mosquito larval habitats. As a consequence, in many areas where irrigated rice now is common we also experience an increased abundance of the well-known malaria vector Anopheles arabiensis.

A key-factor for the build-up of viable mosquito populations, and for the spread of malaria, is that the female mosquitoes are able to find suitable aquatic habitats where they can lay their eggs.

"We know that smells are extremely important for the behaviour of mosquitoes in most phases of their life cycle, but it is only now that we begin to understand what attracts the egg-laying females to rice fields and other egg-laying sites", says Rickard Ignell, leader of the study and professor of chemical ecology at Swedish University of Agricultural Sciences (SLU).

Together with colleagues from SLU and scientists in Ethiopia, Kenya and England he has now shown that gravid females of Anopheles arabiensis are attracted and lay eggs in response to the odour present in the air surrounding rice. The research team has also identified a synthetic rice odour, consisting of a mixture of eight compounds in specific proportions, which triggers the same behaviour, both under laboratory and semi-field conditions.

"This synthetic lure may well become a tool in future control strategies against malaria", says Rickard Ignell, "and it is the first one that targets egg-laying females". "It can be used as an important complement to other control methods that target females searching for blood meals."

As the next step following this pre-field study, the team intends to test the rice odour blend under field conditions to evaluate its efficacy in relation to natural odours in the landscape.

Earlier this year, Rickard Ignell co-authored two other high-profile articles concerning alternative ways to reduce the transmission of malaria. One showed that chicken odours have a deterrent effect on A. arabiensis females, the other that malaria transmission rates can be reduced if certain plant species are included in the mosquitos' diet.

More information

Rickard Ignell, Professor
Department of Plant Protection Biology
Swedish University of Agricultural Sciences, Alnarp, Sweden
+46 (0)40-41 53 11, +46 (0)73-598 48 71, rickard.ignell@slu.se

Article in Scientific Reports

Betelehem Wondwosen, Göran Birgersson, Emiru Seyoum, Habte Tekie, Baldwyn Torto, Ulrike Fillinger, Sharon R. Hill & Rickard Ignell. (2016) Rice volatiles lure gravid malaria mosquitoes, Anopheles arabiensis. Scientific Reports, 6:37930. DOI: 10.1038/srep37930
http://www.nature.com/articles/srep37930

Related articles

Hien DFdS, Dabiré KR, Roche B, Diabaté A, Yerbanga RS, Cohuet A, m.fl. (2016) Plant Mediated Effects on Mosquito Capacity to Transmit Human Malaria. PLoS Pathog 12(8): e1005773. doi:10.1371/journal.ppat.1005773
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005773

Jaleta, K.T., Hill, S.R., Birgersson, G., Tekie, H. & Ignell, R. (2016) Chicken volatiles repel host-seeking malaria mosquitoes. Malaria Journal 15:354. Doi: 10.1186/s12936-016-1386-3.
http://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1386-3

Press image (may be published without charge in articles about these findings, please acknowledge the photographer)

Anopheles arabiensis. Photo: Rickard Ignell