CV-sida
Jun Mei Hu Frisk
I am in my first year of PhD. My main interests are: how does thymidine kinase I excrete into blood in cancer patients and enzymes involved in dTMP synthesis.
Presentation
During my study at Uppsala university, it is fascinated to get into deep knowledge of different diseases and their molecular mechanisms. As a fresh student after finishing my master programme in Biotechnology, I aimed to join scientific world. With close touch with many scientists, I realize that it needs great ambition, endurable effort and sophistic technique to achieve my goal, I think I am ready for the great challenges.
Undervisning
biomedical basic course
Forskning
Mainly, i am interested in different enzymes involving the synthesizing pathway of dTTP and their correlation to diseases. Right now, we are focusing on dTMP kinase and Thyimdine kinase 1/2.
In my routine work, I actively perform experimental research by applying different molecular
methods, such as western blot, RT-qPCR, ELISA, immunohistochemistry, molecular cloning, and bioinformatics. Protein, DNA and RNA preparations are frequently carried out in my research. I have very good experiences on different cell cultures and also I have used bacteria as a model for studying diseases.
Bakgrund
I have finished my Master programme in Biotechnology at
Uppsala University (UU) 2015 autumn
I worked as a project student at Immunology group of
Department of Medical Biochemistry and Microbiology (IMBIM) at UU since January, 2016 to 2018 august. I have studied allergic diseases and how different factors affect mast cells´ homeostasis and function.Signalling pathway of MAP kinases is one of important projects I have carried out. In order to address our scientific questions, we are using mainly murine mast cells derived from bone marrow stem cells (BMMC) as a model, sometimes also human lung cells and skin biopsies from patients and mice.
Handledning
Liya, Wang
Staffan, Eriksson
Gunnar Peljer
Publikationer i urval
Acidic pH is essential for maintaining mast cell secretory granule homeostasis Cell Death & Disease volume 8, page e2785 (2017) doi:10.1038/cddis.2017.206
Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells
J Immunol December 15, 2017, 199 (12) 4132-4141; DOI: https://doi.org/10.4049/jimmunol.1700786
Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules
Front. Immunol., 19 July 2018 | https://doi.org/10.3389/fimmu.2018.01670
Länkar
http://www.jimmunol.org/content/199/12/4132.long
http://www.nature.com/articles/cddis2017206
https://doi.org/10.3389/fimmu.2018.01670