Publications

Research articles and reviews

Leong JX, Raffeiner M, Spinti D, Langin G, Franz-Wachtel M, Guzman AR, Kim JG, Pandey P, Minina AE, Macek B, Hafrén A, Bozkurt TO, Mudgett MB, Börnke F, Hofius D, Üstün S (2022). A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component. EMBO J, 41, e110352 PubMed

Shukla A, Hoffmann G, López-Gonzaléz S, Hofius D, Hafrén A (2022). Salicylic acid and the viral virulence factor 2b regulate the divergent roles of autophagy during Cucumber mosaic virus infection. Autophagy 18, 1450-1463 PubMed

Dvořák Tomaštíková E, Hafrén A, Trejo-Arellano MS, Rasmussen SR, Santos-González J, Sako H, Köhler C, Hennig L, Hofius D (2021). Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis. Plant Physiol. 185, 2003-2021  PubMed

Klionsky DJ, …. Hofius D, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, Feb 8:1-382. doi: 10.1080/15548627.2020.1797280  PubMed

Li Q, Serio R, Schofield A, Liu H, Rasmussen S, Hofius D, and Stone S (2020). Arabidopsis RING-type E3 ubiquitin ligase XBAT35.2 promotes proteasome-dependent degradation of ACD11 to attenuate abiotic stress tolerance. Plant J. 104, 1712-1723 10.1111/tpj.15032 Pubmed

Kushwaha NK, Hafrén A, Hofius D (2019) Autophagy-virus interactions: from antiviral recognition to proviral manipulation. Mol. Plant Pathol. 20, 1211-1216  PubMed

Üstün S, Hofius D (2018) Anti-and pro-microbial roles of autophagy in plant-bacteria interactions. Autophagy 14, 1465-1466  PubMed

Üstün S, Hafrén A, Liu Q, Marshall RS, Minina EA, Bozhkov P, Vierstra RD, Hofius D (2018) Bacteria exploit autophagy for proteasome degradation and enhanced virulence in plants. Plant Cell 30, 668-685    PubMed

Minina EA, Moschou PN, Vetukuri RR, Sanchez-Vera V, Cardoso C, Qinsong Liu Q,
Elander PH, Dalman K, Beganovic M, Lindberg Yilmaz J, Marmon S, Shabala L, Suarez MF, KL, Novák O, Shabala S, Stymne S, Hofius D, Bozhkov PV (2018) Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness. J. Exp. Bot. 69, 1415–1432   PubMed

Avin-Wittenberg T, Baluška F, Bozhkov PV, Elander PH, Fernie AR, Galili G, Hassan A, Hofius D, Isono E, Masclaux-Daubresse RLBC, Minina EA, Peled-Zehavi H, Coll NS, Sandalio LM, Satiat-Jeunemaitre B,Sirko A, Testillano PS, Batoko H (2018) Autophagy-related approaches for improving nutrient use efficiency and crop yield protection.
J. Exp. Bot. 69, 1335–1353   PubMed

Liu Q, Vain T, Viotti C, Doyle SM, Tarkowská D, Novák O, Zipfel C, Sitbon F, Robert S, Hofius D (2018) Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation. Mol. Plant  11, 553-567   PubMed

Hafrén A, Üstün S, Hochmuth A, Svenning S, Johansen T, Hofius D (2018) Turnip mosaic virus counteracts selective autophagy of the viral silencing suppressor HCpro. Plant Physiol. 175, 649-662   PubMed

Hafrén A, Hofius D (2017) NBR1-mediated antiviral xenophagy in plant immunity. Autophagy 29, 1-2   PubMed

Üstün S, Hafrén A, Hofius D (2017) Autophagy as a mediator of life and death in plants. Curr. Opin. Plant Biol. 40, 122-130   PubMed

Liu H, Ravichandran S, Teh O, McVey S, Lilley C, Teresinski HJ, Mullen RT, Hofius D, Prithiviraj B, Stone SL (2017) The RING-type E3 ligase XBAT35.2 is involved in cell death induction and pathogen response. Plant Physiol. 175, 1469-1483   PubMed

Hofius D, Li L, Hafrén A, Coll NS (2017). Autophagy as an emerging arena for plant-pathogen interactions. Curr Opin Plant Biol. 38, 117-23   Pubmed

de Jonge J, Hofius D, Hennig L (2017) Salicylic acid interferes with GFP fluorescence in vivo J. Exp. Bot. 68, 1689-1696   PubMed

Hafrén A, Macia JL, Love AJ, Milner JJ, Drucker M, Hofius D (2017) Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles Proc. Natl. Acad. Sci. U S A 114, E2026-E2035   Pubmed

Klionsky DJ, Abdelmohsen K, ..., Hofius D, et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy 12, 1-222   PubMed

Mozgova I, Wildhaber T, Liu Q, Abou-Mansour E, L’Haridon F, Métraux J-P, Gruissem W, Hofius D, and Hennig L (2015). Chromatin assembly factor CAF-1 represses priming of plant defence response genes, Nature Plants Article No 15127   PubMed

Munch D*, Teh OK*, Malinovsky FG*, Liu Q, Vetukuri RR, El Kasmi F, Brodersen P, Hara-Nishimura I, Dangl JL, Petersen M, Mundy J, and Hofius D (2015). Retromer contributes to immunity-associated cell death in Arabidopsis. Plant Cell 27, 463-79. (*co-first authors)

Minina EA, Bozhkov P, and Hofius D (2014). Autophagy as an initiator or executioner of programmed cell death in plants. Trends Plant Sci. 19, 692-7.

Munch D, Rodriguez E, Bressendorff S, Park OK, Hofius D, and Petersen M (2014) Autophagy deficiency leads to accumulation of ubiquitinated proteins, ER stress, and cell death in Arabidopsis. Autophagy 10, 1579-87.

Teh OK and Hofius D (2014). Membrane trafficking and autophagy in pathogen-triggered cell death and immunity. J. Exp. Bot. 65, 1297-312.

Simanshu DK, Zhai X, Munch D, Hofius D, Markham JE, Bielawski J, Bielawska A, Malinina L, Molotkovsky JG, Mundy JW, Patel DJ, and Brown RE (2014). Arabidopsis accelerated-cell-death11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels. Cell Rep.6, 388-99.

Petersen M, Hofius D, and Andersen SU (2014). Signaling unmasked: autophagy and catalase promote programmed cell death. Autophagy 10, 520-1.

Hackenberg T, Juul T, Auzina A, Gwizdz S, Malolepszy A, van der Kelen K, Dam S, Bressendorff S, Lorenzen A, Roepstorff P, Lehmann Nielsen K, Jørgensen JE, Hofius D, van Breusegem F, Petersen M, and Andersen SU (2013). Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell 25, 4616-26.

Hofius D, Munch D, Mundy J, and Petersen M (2011). Role of autophagy in disease resistance and hypersensitive response associated cell death. Cell Death Differ. 18,1257-62.

Vogel F, Hofius D, Paulus KE, Jungkunz I, and Sonnewald U (2011). The second face of a known player: Arabidopsis silencing suppressor AtXRN4 acts organ specifically. New Phytol., 189, 484-493.

Palma K, Thorgrimsen SP, Fiil BK, Malinovsky FG, Nielsen HB, Brodersen P, Hofius D, Petersen M, and Mundy J (2010). Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor. PLoS Pathog. 6, e1001137.

Malinovsky FG, Brodersen P, Fiil BK, McKinney LV, Thorgrimson SP, Beck M, Nielsen HB, Robatzek S, Petersen M, Hofius D, and Mundy J (2010). Lazarus1, a DUF300 protein, contributes to programmed cell death associated with Arabidopsis acd11 and the hypersensitive response. PLoS One 5, e12586s.
 
Hafrén A, Hofius D, Rönholm G, Sonnewald U, and Mäkinen K (2010). HSP70 and its co-chaperone CPIP promote Potato virus A infection by regulating functions of the viral coat protein. Plant Cell 22, 523-535.

Hofius D, Schultz-Larsen T, Joensen J, Tsitsigiannis DI, Petersen NH, Jørgensen LB, Mattsson O, Jones JD, Mundy J, and Petersen M (2009). Autophagic components contribute to hypersensitive cell death in Arabidopsis. Cell 137, 773-783.

Hofius D, Mundy J, and Petersen M (2009). Self-consuming immunity in plants. Autophagy 5, 1206-7.

Abbasi AR, Saur A, Hennig P, Tschiersch H, Hajirezaei M, Hofius D, Sonnewald U, and Voll LM (2009). Tocopherol deficiency in transgenic tobacco plants leads to accelerated senescence. Plant Cell Environ. 32, 144-157.

Petersen NH, Joensen J, McKinney LV, Brodersen P, Petersen M, Hofius D, and Mundy J (2009). Identification of proteins interacting with Arabidopsis ACD11. J. Plant Physiol. 166, 661-666.

Petersen NH, McKinney LV, Pike H, Hofius D, Zakaria A, Brodersen P, Petersen M, Brown RE, and Mundy J (2008). Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant. FEBS J. 275, 4378-88.

Hofius D, Tsitsigiannis DI, Jones JD, and Mundy J (2007). Inducible cell death in plant immunity. Sem. Cancer Biol. 17, 166-187.

Kronberg K, Vogel F, Rutten T, Hajirezaei M-R, Sonnewald U, and Hofius D (2007). The silver lining of a viral agent: Increasing seed yield and harvest index in Arabidopsis by ectopic expression of the potato leaf roll virus movement protein. Plant Physiol. 145, 905-918 (recommended by Faculty1000)

Hofius D, Maier AT, Dietrich C, Jungkunz I, Börnke F, Maiss E, and Sonnewald U (2007). Capsid protein-mediated recruitment of a novel subset of host DnaJ-like chaperones is required for Potato virus Y infection in tobacco plants. J. Virol. 81, 11870-80 (cover caption, J Virol. 82, March 2008).

Vogel F, Hofius D, and Sonnewald U (2007). Intracellular trafficking of the potato leaf roll virus (PLRV) 17 kDa movement protein in transgenic Arabidopsis thaliana. Traffic 8, 1205-1214.

Ding L, Hofius D, Hajirezaei MR, Fernie AR, Börnke F, and Sonnewald U (2007). Functional analysis of the essential bifunctional enzyme 3-dehydroquinate dehydratase / shikimate dehydrogenase in transgenic tobacco plants: evidence for redundancy of plastidial shikimate biosynthesis J. Exp. Bot. 58, 2053-2067.

Abbasi AR, Hajirezaei M, Hofius D, Sonnewald U, and Voll LM (2007) Specific roles of alpha- and gamma-tocopherol in abiotic stress responses of transgenic tobacco plants. Plant Physiol. 43, 1720-1738.

Birschwilks M, Haupt S, Hofius D, and Neumann K (2006). Transfer of phloem mobile substances from the host plants to the holoparasite Cuscuta spec. J. Exp Bot. 57, 911-921.

Hofius D, Hajirezaei MR, Geiger M, Tschiersch H, Melzer M, and Sonnewald U. (2004). RNAi-mediated tocopherol deficiency impairs photoassimilate export in transgenic potato plants. Plant Physiol. 135, 1256-1268.

Hofius D and Sonnewald U (2003). Vitamin E biosynthesis: Biochemistry meets cell biology. Trends Plant Sci. 8, 6-8.

Chen S, Hofius D, Sonnewald U, and Börnke F (2003). Temporal and spatial control of gene silencing in transgenic plants by inducible expression of double-stranded RNA. Plant J. 36, 731-740.

Hofius D, Herbers K, Melzer M, Omid A, Tacke E, Wolf S, and Sonnewald U (2001). Evidence for expression level dependent modulation of carbohydrate status and viral resistance by the potato leafroll virus movement protein in transgenic tobacco plants. Plant J. 28, 529-544.

Book chapters

Hofius D and Börnke F (2007). Photosynthesis, carbon metabolism and sink-source relations. In: Potato biology and biotechnology: advances and perspectives (ed. Dick Vreugdenhill); Elsevier, Amsterdam, pp 257–285.

Hofius D, Tropf S, Geiger M, U. Sonnewald, and Herbers K. (2006). Vitamin E: Nutritional significance, biosynthesis, metabolic engineering and function in plants and animals In: Plant Genetic Engineering Vol 7: Metabolic Engineering and Molecular Farming (ed. Jaiwal PK) Studium Press LLC, Houston, Texas 77072, USA, pp 117-157.

Patents

Bozhkov P, Minina EA, Moschou PO, Hofius D (75% inventor on disease resistance), Stymne S (2017) Transcriptional stimulation of autophagy improves plant fitness, SweTree Technologies, (WO 2017/095320).

Hofius D, Börnke F, and Sonnewald U (2004/2005). Method for the production of transgenic plants with increased virus resistance by silencing of vegetable DnaJ-like proteins (US11039722, WO/2004/009821).

Other publications

Hofius D (2003). Suppression von Wirtsfaktoren als alternative Strategie zur Erzeugung von Potyvirus-resistenten Pflanzen. Vortr. Pflanzenzüchtung 63, 127-136.

Börnke F, Biemelt S, Hofius D, Hajirezaei MR, S. Lepsky S, and U. Sonnewald (2002). Gentechnik in der Pflanzenzüchtung – Stand und Perspektiven. Vortr. Pflanzenzüchtung 54, 153-161.

Pedagogic publications

Hofius D (2010). Student motivation and activation by research-based laboratory exercises. In: Improving University Science Teaching and Learning - Pedagogical projects 2008, Volume 1, Department of Science Education, University of Copenhagen. Denmark, ISSN: 1904-2019. E-version at http://www.ind.ku.dk/publikationer/knud, pp. 61-75.