Cecilia Ley

As a veterinary pathologist, I have a broad interest in animal diseases, but I am particularly interested in diseases that affect companion animals. As a specialist in veterinary pathology, I have broad knowledge in the subject and can contribute with expertise in several different contexts. In addition to research and teaching, my employment at SLU includes performing diagnostic pathology on biopsies from patients seen at the University Animal Hospital and the Ambulatory Clinic at SLU. I thoroughly enjoy teaching both at undergraduate and postgraduate level, and I think it is especially rewarding when teaching and research is linked, for example through students' degree projects. 

I teach in the courses Special Pathology and Diagnostic Pathology, and I have been course leader for Special Pathology in the Veterinary program for many years. The teaching has mainly involved necropsies, diseases of the endocrine system, neuropathology and histopathology. Further, I am mentor for veterinarians who participate in specialist training in pathology at BVF.

My current research is focused on diseases of cats and dogs. I lead projects about the joint disease osteoarthritis in cats and encephalitis in dogs. I also work in projects aiming to increase our knowledge about chest malformations in Bengal cats, and 'staggering disease' and diabetes mellitus in cats. 

In my research on osteoarthritis in cats, underlying causes, disease development and how the diagnosis of the disease can be improved are investigated. I am mainly interested in how inflammation and metabolic parameters (such as body fat and bone density) are related to osteoarthritis. In the latest project, "Mechanisms of joint disease in cats - from whole body examination to molecular changes", the focus is on associations between osteoarthritis and bone-stimulatory substances. In the studies, whole-body computed tomography is combined with different types of tissue examinations. 

In the project "Genetic background to flat chest in Bengal cats", the goal is to determine the genetic defect/s associated with malformation of the chest.

In collaboration with colleagues from Sweden and Germany I have ongoing research on 'staggering disease' in cats. 'Staggering disease' is a serious infectious disease that causes inflammation of the brain and spinal cord.

The research on encephalitis in dogs is a collaboration between SLU, the Swedish Veterinary Agency (SVA), Uppsala University, Ludwig Maximilian University and Friedrich-Loefller Institute. The studies aim to increase our understanding of encephaliltis in dogs, investigate known and so far unknown viruses as causes and to perform comparative studies to people.

Projects

• 2022-2025 Viral encephalitides in dogs and humans – identification of causes and disease patterns in Swedish populations (Skriftställare Birgitta Carlsson Fund, SLU) (project leader)
• 2017-2021 Mechanisms of joint disease in cats - from whole-body examination to molecular changes (Stiftelsen Sällskapsdjurens forskningfond, SLU) (project leader)
• 2016-2018 Genetic Background to Flat Chest in the Bengal cat (Agria and SKK Research Fund) (co-applicant)
• 2014-2016 Feline osteoarthritis - morphology, diagnostic methods and influence of obesity (Agria and SKK Research Fund) (project leader)
• 2015-2016 Osteoarthritis in cats - an inflammatory condition related to obesity? (Stiftelsen Sällskapsdjurens forskningfond, SLU) (project leader)
• 2011-2013 Inflammatory mediators of equine osteoarthritis (The Swedish-Norwegian Foundation for Equine Research) (co-applicant)

After my veterinary degree in 1994, I worked for a few years as a clinic veterinarian in Sweden and abroad (Great Britain and Australia).

In 2003 I started a postgraduate position in pathology at SLU, focusing on the role of inflammation in osteoarthritis in horses. In 2010 I defended my thesis "Inflammatory Response in Equine Joints - Studies on Proinflammatory Cytokines in Diseased Joints and Chondrocyte Cultures".

Employment history after dissertation

• 2016- Senior lecturer in veterinary pathology, SLU (absence of leave Sept 2021-Aug 2022, July 2017-Dec 2017)
• 2021-2022 Laboratory veterinarian (veterinary pathologist), National Veterinary Institute (SVA), Uppsala
• 2017 Senior lecturer in veterinary pathology, Murdoch University, Perth, Australia
• 2013-2016 Lecturer in veterinary pathology, SLU
• 2010-2013 Resident in veterinary pathology, SLU

Degrees/examinations

• Diplomate of European College of Veterinary Pathologists (ECVP) 2013
• Doctor of Veterinary Medicine (SLU) 2010
• Australian National Veterinary Exams 1997
• Master of Science in Veterinary Medicine (SLU) 1994

Thilén E et al. Evidence of rustrela virus-associated feline staggering disease in Sweden since the 1970s. Acta Vet Scand. 2024 Nov 23;66(1):59. doi: 10.1186/s13028-024-00783-5.

Strage EM et al. Insulin release from isolated cat islets of Langerhans. Domest Anim Endocrinol. 2024 Apr:87:106836. doi: 10.1016/j.domaniend.2023.106836.

Matiasek K et al. Mystery of fatal 'staggering disease' unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats. Nat Commun. 2023 Feb 4;14(1):624. doi: 10.1038/s41467-023-36204-w.

Ley C et al. Falciform fat:femur length ratio provides a novel method for objective postmortem estimation of total body fat in overweight and obese cats. J Vet Diagn. Invest. 2022 Jan 10; 1–9

Ley CJ et al. Computed tomography is superior to radiography for detection of feline elbow osteoarthritis. Res Vet Sci. 2021 Nov;140:6-17

Ley C et al. Acetabular margin changes in feline hip joints - Implications for radiologic diagnosis and development of osteoarthritis. Res Vet Sci. 2021 Jul;137:243-251

Strage EM et al. Homeostasis model assessment, serum insulin and their relation to body fat in cats. BMC Vet Res. 2021 Jan 18;17(1):34

Blomqvist MA et al. Presence of CD3 + and CD79a + lymphocytes in the pituitary gland of dogs at post-mortem examination. J Comp Pathol. 2020, Apr;176:116-121

Mellgren T et al. Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect. Biomed. Mater. 2021;16:035018

Hedenqvist P et al. The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits. PLoS One. 2020 May 21;15(5):e0233530

Trbakovic A et al. A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model. J Dent. 2018 Mar;70:31-39

Leijon A et al. Cartilage lesions in feline stifle joints – associations with articular mineralizations and implications for osteoarthritis. Res Vet Sci. 2017;114:186-193

Blomström AL, Ley C, Jacobson M. Astrovirus as a possible cause of congenital tremor type AII in piglets? Acta Vet Scand. 2014;56:82

Löfgren M et al. Cell and matrix modulation in prenatal and postnatal equine growth cartilage, zones of Ranvier and articular cartilage. J Anat. 2014;225(5):548-568

Svala E et al. Effects of interleukin-6 and interleukin-1 on expression of growth differentiation factor-5 and Wnt signaling pathway genes in equine chondrocytes. AJVR. 2014;75(2):132-140

Web-baserad populärvetenskaplig forskningspresentation

https://www.slu.se/forskning/kunskapsbank/publicerat/sport--och-sallskapsdjur/katt/metod-for-objektiv-hullbedomning-vid-obduktion-av-katt/
https://www.slu.se/forskning/kunskapsbank/publicerat/sport--och-sallskapsdjur/katt/vavnadsforandringar-i-knaleden-hos-katt/ 
https://www.slu.se/hoftledsartroskatt  
https://www.slu.se/hoftledsartroskatthttps://www.veterinarmagazinet.se/2021/09/dt-behovs-for-tidig-diagnos-av-hoftledsartros-hos-katt/