Eva Tyden

I started as a student in the master program in Biotechnology at SLU in 1998. After my master degree I kept on as a PhD-student in Pharmacology and Toxicology. My aim of the thesis was to gain more understanding of the drug metabolism in the horse by performing a molecular characterization on gene and protein level of CYP-enzymes and the ABC-transport proteins (efflux proteins) in tissues involved in drug metabolism, such as intestines, liver, kidneys and upper respiratory airways in the horse.

My research today is to understand the mechanism behind drug resistance in parasitic nematodes. Interestingly, drug metabolizing pathways and efflux proteins are important key factors for the understanding of how parasitic worms develop resistance to anthelmintic drugs. Knowledge of drug metabolizing pathways in parasitic worms will lead to an understanding of the mechanism behind anthelmintic resistance.

My research focus is on understanding molecular mechanism of anthelmintic resistance and providing solutions for equine parasite control. My background in molecular biology and a PhD in pharmacology allows me to try to find markers for resistance to be applied in equine parasitology. Research efforts have concentrated on the following topics: 1) Understanding anthelmintic resistance in the equine roundworm 2) Evaluation of the clinical efficacy of anthelmintic drugs 3) Studying epidemiology of equine strongyle parasites, and 4) Alternative methods to drugs to control parasite infection in the field

I have collaboration with different reseach groups at Uppsala University, SVA, INRA and University of Copenhagen. I am a memeber of the Veterinary Network of Pharmacology in the EUFEPS organisation.