Sara Hägglund

I hold a DVM (1999), a PhD in Ruminant Medicine (2006) and an associate professorship in Veterinary medicine, with focus on ruminant infection and immunity (2018). I currently work with research and supervision, but also as course leader and teacher for the clinical ruminant parts in the veterinary education and as clinician in the ruminant clinic. My overall goal is to improve cattle welfare and production as well as to contribute to the global goals for sustainable development in a One Health perspective.

Bovine Respiratory Syncytial Virus (BRSV) - Tracing sources and transmission pathways between herds to design adapted biosecurity measures for the development of a sustainable BRSV control program. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2017-01-01 to 2020-12-31 Grant number: 2016-00463 https://app.dimensions.ai/details/grant/grant.8444911 (co-PI)

New treatment approaches for bovine respiratory disease. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2016-01-01 to 2021-12-31. Grant number: 2016-01770 https://app.dimensions.ai/details/grant/grant.8443817 (PI)

Strengthening Animal Production and Health through the Immune Response  European Commission (Brussels) 2015-03-01 to 2019-03-01 Grant number: 633184 https://grants.uberresearch.com/501100000780/193183/Strengthening-Animal-Production-and-Health-through-the-Immune-Response (co-PI)

Host response gene signatures associated with FMDV infection, vaccination and persistence. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2014-11-01 to 2016-12-31 Grant number: 2014-01844  https://app.dimensions.ai/details/grant/grant.8444391 (I)

Bluetongue and Immunostimulating Complexes (BT-ISCOMs): Development and evaluation of a DIVA subunit vaccine. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2010-01-01 to 2012-12-31 Grant number: 2009-1593  https://grants.uberresearch.com/501100001862/19723/Bluetongue-and-Immunostimulating-Complexes-BT-ISCOMs-Development-and-evaluation-of-a-DIVA-subunit-vaccine (co-PI)

Development and comparative evaluation of three new generation BRSV DIVA vaccines and a corresponding DIVA test. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm)2009-01-01 to 2009-12-31 Grant number: 2010-2158 https://grants.uberresearch.com/501100001862/25205/Development-and-comparative-evaluation-of-three-new-generation-BRSV-DIVA-vaccines-and-a-corresponding-DIVA-test (PI, coordinator)

Evaluation of vaccines against Bovine Respiratory Syncytial Virus in cattle. Swedish farmers’ foundation for agricultural research (Stockholm) 2008-01 to 2010-12 Grant number: Kött H0750358 (PI)

Research is carried out in collaboration with national and international partners (National Veterinary Institute SVA, SciLifeLab, Uppsala University, Akademiska sjukhuset, Växa Sverige, ENVT/INRA/ANSES/Ambiotis France, TPI, UK, Univ Glasgow, Scotland, FLI, Germany).

1. 1. Hägglund S, Laloy E, Alvarez I, Guo Y, Hallbrink Ågren G, Yazdan Panah H, Widgren A, Bergquist J, Hillström A, Baillif V, Saias L, Dubourdeau M, Timsit E, Valarcher J.F. Effects of early treatment with nonsteriodal anti-inflammatory drugs (NSAIDs) on the bronchoalveolar lavage proteome and oxylipins during bovine respiratory syncytial virus (BRSV) infection. Submitted
      
      
   2. Alvarez I, Ducatez M, Guo Y, Lion A, Widgren A, Dubourdeau M, Baillif V, Saias L, Zohari S, Bergquist J, Meyer G, Valarcher JF, Hägglund S. Proteomic and Lipidomic Profiling of Calves Experimentally Co-Infected with Influenza D Virus and Mycoplasma bovis: Insights into the Host-Pathogen Interactions. 2024 Feb 27;16(3):361. doi: 10.3390/v16030361.
      
      
   3. Sarry M, Bernelin-Cottet C, Michaud C, Relmy A, Romey A, Salomez A-L, Renson P, Contrant M, Berthaud M, Huet H, Jouvion G, Hägglund S, Valarcher J.F, Bakkali Kassimi1 L, and Blaise-Boisseau S. Development of a primary cell model drived from porcine dorsal soft palate for foot-and-mouth disease virus research and diagnosis Front Microbiol. 2023 Sep 29;14:1215347. doi: 10.3389/fmicb.2023.1215347.
      
      
   4. Gaudino M, Valarcher J.F, Hägglund S, Näslund K, Zohari S, Ducatez M.F, Gilles Meyer Molecular and genetic characterization of bovine parainfluenza type 3 European field and vaccine strains Infection, Genetics and Evolution 113. 2023. 105483. doi: 10.1016/j.meegid.2023.105483
      
      
   5. Alvarez I, Hägglund S, Näslund K, Eriksson A, Ahlgren E, Ohlson A, Ducatez MF, Meyer G, Valarcher JF, Zohari S. Detection of Influenza D-Specific Antibodies in Bulk Tank Milk from Swedish Dairy Farms. Viruses. 2023 Mar 24;15(4):829. doi: 10.3390/v15040829.
      
      
   6. Fix J, Descamps D, Galloux M, Ferret C, Bouguyon E, Zohari S, Näslund K, Hägglund S, Altmeyer R, Valarcher JF, Riffault S, Eléouët JF. Screening antivirals with a mCherry-expressing recombinant bovine respiratory syncytial virus: a proof of concept using cyclopamine. Vet Res. 2023 Apr 17;54(1):36. doi: 10.1186/s13567-023-01165-x.
      
      
   7. Johnson PCD, Hägglund S, Näslund K, Meyer G, Taylor G, Orton RJ, Zohari S, Haydon DT, Valarcher JF. Evaluating the potential of whole-genome sequencing for tracing transmission routes in experimental infections and natural outbreaks of bovine respiratory syncytial virus. Vet Res. 2022 Dec 12;53(1):107. doi: 10.1186/s13567-022-01127-9.
      
      
   8. Hägglund S, Näslund K, Svensson A, Lefverman C, Enül H, Pascal L, Siltenius J, Holzhauer M, Delabouglise A, Österberg J, Alvåsen K, Olsson U, Eléouët JF, Riffault S, Taylor G, Rodriguez MJ, Garcia Duran M, Valarcher JF. Longitudinal study of the immune response and memory following natural bovine respiratory syncytial virus infections in cattle of different age. PLoS One. 2022 Sep 16;17(9):e0274332. doi: 10.1371/journal.pone.0274332.
      
      
   9. Lion A, Secula A, Rançon C, Boulesteix O, Pinard A, Deslis A, Hägglund S, Salem E, Cassard H, Näslund K, Gaudino M, Moreno A, Brocchi E, Delverdier M, Zohari S, Baranowski E, Valarcher JF, Ducatez MF, Meyer G. Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: a Disease Severity Linked with Overexpression of IFN-γ as a Key Player of the Enhanced Innate Immune Response in Lungs Microbiol Spectr. 2021 Dec 22;9(3):e0169021. doi: 10.1128/spectrum.01690-21.
   10. Valarcher, J.F., Hägglund S., Näslund K., Jouneau L., Malmström E.; Boulesteix O., Pinard A., Leguéré D., Deslis A., Gauthier, D., Dubuquoy C., Pietralunga V., Remot A., Falk A., Shevchenko G., Bergström Lind S.B., Von Brömssen C., Vargmar K., Zhang B., Kwong P.D., Rodriguez M.J., Duran M.G., Schwartz-Cornil I., Taylor G., Riffault S. Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies. Vaccines 2021, 9, 236. https:// doi.org/10.3390/vaccines9030236 
       
       
   11. Alvarez I.J., Fort M., Pasucci J., Moreno F., Gimenez H., Näslund K., Hägglund S., Zohari S. Valarcher J.F. Seroprevalence of influenza D virus in bulls in Argentina. J Vet Diagn Invest. 2020 Jul;32(4:585-588. doi: 10.1177/1040638720934056. Epub 2020 Jun 18.
   12. Riffault S., Hägglund S., Guzman E., Näslund K., Jouneau L., Dubuquoy C., Pietralunga V., Laubreton D., Boulesteix O., Gauthier D., Remot A., Boukaridi A., Falk A., Shevchenko G., Lind S.B., Vargmar K., Zhang B., Kwong P.D., Rodriguez M.J., Duran M.G., Schwartz-Cornil I., Eléouët J.F., Taylor G., Valarcher J.F. A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies. Vaccines 2020 May 18;8 doi: 10.3390/vaccines8020231.
       
       
   13. Hägglund S., Laloy E., Näslund K., Pfaff F., Eschbaumer M., Romey A., Relmy A.,Rikberg A.,Svensson A., Huet H., Gorna K., Zühlke D., Riedel K., Beer M., Zientara S., Bakkali-Kassimi L., Blaise-Boisseau S. , Valarcher J.F. Model of persistent foot-and-mouth disease virus infection in multilayered cells derived from bovine dorsal soft palate. Transbound Emerg Dis. 2020 Jan;67(1):133-148. doi: 10.1111/tbed.13332.
       
       
   14. Pfaff F., Hägglund S., Zoli M. Laloy E., Blaise-Boisseau S. Laloy E., Koethe S., Zühlke D., Riedel K., Zientara S., Bakkali Kassimi L., Valarcher Jf., Höper D., Beer M., Eschbaumer M. Proteogenomics Uncovers Critical Elements of Host Response in Bovine Soft Palate Epithelial Cells Following In Vitro Infection with Foot-And-Mouth Disease Virus. Viruses. 2019 Jan 12;11  doi: 10.3390/v11010053.
       
       
   15. Salem E., Hägglund S., Cassard H., Corre T., Näslund K., Foret C., Gauthier D., Pinard A., Delverdier M., Zohari S., Valarcher J.F., Ducatez M., Meyer G. Pathogenesis, host innate immune response and aerosol transmission of Influenza D virus in cattle. J Virol. 2019 Jan 23. pii: JVI.01853-18. doi: 10.1128/JVI.01853-18.
       
       
   16. Delabouglise A., James A., Valarcher JF., Hägglund S., Raboisson D., Rushton J. Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France. PLoS One. 2017 Dec 5;12(12):e0189090. doi: 10.1371/journal.pone.0189090.
       
       
   17. Hägglund S., Blodörn K., Näslund K., Vargmar K., Bergström Lind S., Mi J., Araínga M., Riffault S., Taylor G., Pringle J., Valarcher J.F. Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virus- Insights in pathogenesis and perspectives for new treatments. PLoS ONE. 2017 12(10): e0186594 doi:10.1371/journal.pone.0186594.
       
       
   18. Malmsten A., Malmsten J., Blomqvist G., Näslund K., Vernersson C., Hägglund S., Dalin AM., Ågren EO., Valarcher J.F. Serological testing of Schmallenberg virus in Swedish wild cervids from 2012 to 2016.BMC Vet Res. 2017 Apr 4;13(1):84. doi: 10.1186/s12917-017-1005-8.
       
       
   19. Blodörn K., Hägglund S., Gavier-Widen D., Eléouët J-F., Riffault S., Pringle J., Taylor G., Valarcher J.F. A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity. BMC Vet Res. 2015 Mar 25;11:76. doi: 10.1186/s12917-015-0389-6.
       
       
   20. Valarcher J.F., Hägglund S., Juremalm M., Blomqvist G., Renström L., Zohari S., Leijon M., Chirico J. Tick-borne encephalitis. OIE Scientific and Technical Review. Rev. Sci. Tech. Off. Int. Epiz., 2015, 34 (2), 453-466.
       
       
   21. Anderson J., Hägglund S., Bréard E., Riou M., Zohari S., Comtet L., Elvander M., Blomqvist G., Zientara S., Valarcher JF. Strong protection induced by an experimental DIVA subunit vaccine against bluetongue virus serotype 8 in cattle. Vaccine. 2014 Nov 20;32(49):6614-21.
       
       
   22. Blodörn K., Hägglund S., Fix J., Dubuquoy C., Makabi-Panzu B., Thom M., Karlsson P., Roque JL., Karlstam E., Pringle J., Eléouët JF, Riffault S., Taylor G., Valarcher JF. Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies. PLoS One. 2014 Jun 19;9(6):e100392. doi: 10.1371/journal.pone.0100392.
       
       
   23. Hägglund S., Hu K., Blodörn K., Makabi-Panzu B., Gaillard AL., Ellencrona K., Chevret D., Thorpe M., Hellman L., Lövgren-Bengtsson K., Riffault S., Taylor G., Valarcher JF., Eléouët JF. Characterization of an experimental vaccine for bovine respiratory syncytial virus. Clinical and Vaccine Immunology. Clin Vaccine Immunol. 2014 Jul;21(7):997-1004. doi: 10.1128/CVI.00162-14.
       
       
   24. Anderson J, Breard E, Lövgren Bengtsson K, Gronvik KO, Zientara S, Valarcher JF, Hägglund S. Purification, stability, and immunogenicity analyses of five bluetongue virus proteins for use in development of a subunit vaccine that allows differentiation of infected from vaccinated animals. Clinical and Vaccine Immunology 2014 Mar;21(3):443-52.
       
       
   25. Anderson J., Hägglund S., Breard E., Comtet L., Lövgren Bengtsson K., Pringle J., Zientara S., Valarcher JF. Evaluation of the Immunogenicity of an Experimental Subunit Vaccine That Allows Differentiation between Infected and Vaccinated Animals against Bluetongue Virus Serotype 8 in Cattle. Clinical and Vaccine Immunology 2013 Aug;20(8):1115-22.
       
       
   26. Hägglund, S., Hu, K.F., Vargmar, K., Poré, L., Olofson, AS., Blodörn, K., Anderson, J., Ahooghalandari, P., Pringle, J., Taylor, G., and Valarcher, J.F. Bovine respiratory syncytial virus ISCOMs – immunity, protection and safety in young conventional calves. Vaccine. 2011 Nov 3;29(47):8719-30.
       
       
   27. Liu, L., Hägglund, S., Hakhverdyan, M., Alenius, S., Larsen, L.E., Bélak, S. Molecular epidemiology of Bovine Coronavirus based on comparative analyses of the S gene. Journal of Clinical Microbiology 2006 44 (3) 957-960.
       
       
   28. Hägglund, S., Svensson, C., Emanuelson, U., Valarcher, J.F., Alenius, S. Dynamics of virus infections involved in the bovine respiratory disease complex in Swedish dairy herds. Veterinary Journal. 2006 Sep;172(2):320-8.
       
       
   29. Almeida, R. S., Domingues, H. G., Spilki, F. R., Larsen, L. E., Hägglund, S., Bélak, S., Arns, C. W. BRSV subgroup B is circulating in Brazil. The Veterinary Record. 2006 May 6;158(18):632-4.
       
       
   30. Hägglund, S., Hjort, M., Öhagen, P., Törnqvist, M., Alenius, S. A six-year study on respiratory viral infections in a bull testing facility. Veterinary Journal. 2006 May;173(3):585-93.
       
       
   31. Hakhverdyan, M., Hägglund, S., Larsen, L.E., Belak, S. Evaluation of a single-tube fluorogenic RT-PCR assay for detection of bovine respiratory syncytial virus in clinical samples. Journal of Virological Methods 2005 123, 195-202.
       
       
   32. Hägglund, S., Hu, K.F., Larsen, L.E., Hakhverdyan, M., Valarcher, J.F., Taylor, G., Morein, B., Belak, S., Alenius, S. Bovine respiratory syncytial virus ISCOMs--protection in the presence of maternal antibodies. Vaccine 2004 23, 646-655.
       
       

       Book chapters

       (2016) Hägglund, S. and Valarcher, J.F. Bovine Respiratory Syncytial Virus In: Molecular Detection of Animal Viral Pathogens, Taylor & Francis Group (ed. Liu, D.).

       (2010) Valarcher, J. F., Hägglund, S. Bovine coronavirus In: Infectious and Parasitic Diseases of Livestock (eds Lefèvre P.C., Blancou J., Chermette, R).

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