Cattle: Limited access to water for high-producing dairy cows (LN119)
Project duration september - november, 2024
This study aims to develop new knowledge to use available water resources on Swedish farms more effectively. This will potentially provide a solution for Swedish farmers experiencing water scarcity without negatively affecting production and animal welfare. Certain regions in Sweden periodically suffer from low groundwater levels, especially during summer. The Swedish Animal Welfare Act specifies requirements for oversight, feed and water, but the wording is unclear. It states: “Animals shall be provided with sufficient amount of feed and water of good quality. Feed, water and feeding routines shall be adapted to the needs of the animal,” but it does not further specify what this entails. The common practice is to offer the cows ad libitum access to fresh water around the clock. However, studies have shown that cows in those systems tend to use more water than they actually need. In this study, we want to investigate the possibilities of limiting access to water for high-producing dairy cows without negatively affecting their production and welfare.
Contact researchers
Anna Jansson, anna.jansson@slu.se, tele +18672106
Lea Managos, PhD student, lea.managos@slu.se, tele, +46722380077
Other participants in the project
Sammy Pettersson, research tehnician, sammy.pettersson@slu.se, tele +4618672114
Cattle: Preventing mastitis in dairy cows: unravelling transmission routes and reducing the use of antibiotics (LN110)
Project completed 2024
Mastitis is the most prevalent production disease in dairy herds world-wide, affecting animal welfare and production. Mastitis-causing bacteria are contagious and environmental pathogens, based upon important reservoirs and modes of transmission of each group. Social and behavioural interactions play a crucial role in the transmission of diseases on dairy farms. However, observational studies of social behaviour provide insufficient information to identify transmission routes.
Nowadays, Precision livestock farming technologies offer an excellent opportunity to continuously monitor the animals and understand the transmission routes of this multifactorial disease. Previous studies of our research group described the heterogeneous nature of dyadic interactions between cows, indicating a non-random movement in the herd. Particularly, proximity loggers provide information about dyadic spatial interactions between animals, which can be used to permanently monitor the social behaviour of dairy cows and estimate spatial occupancy by applying trilateration algorithms.
In addition, automated milking systems collect daily information about individual cows' milk production (e.g., milk yield and somatic cell count). The inclusion of subclinical conditions in mastitis control protocols (i.e., somatic cell count information) in dairy cattle has been one major advance in dairy health. Diseases in dairy cows can lead to decreased milk production, as well as increased use of antibiotics and other treatments, which can contribute to the development of antibiotic-resistant bacteria that can be harmful to humans and the environment. Therefore, the application of preventive measures to reduce the incidence of mastitis in dairy cows will promote the principles of One Health in the dairy industry.
Bearing this in mind, we will explore the relationship between the social networks and area occupancy of dairy cows with the individual somatic cell count data. The results provided by this pilot study will provide a baseline for understanding how the social interactions and proximity between dairy cows could impact their somatic cell count. Based on these findings, we will design a long-term project to unravel the transmission routes of mastitis-causing bacteria within barns and to design prevention and intervention protocols for transmissible diseases in dairy cows.
Contact researcher
Hector Marina, hector.marina@slu.se, tele +46793506609
Cattle: Brackish water as drinking water for high-producing dairy cows
Project: January 2024 - May 2024
Due to periodic water scarcity in certain parts of Sweden where cattle production is common, it is necessary to investigate possible alternative drinking water sources for cattle. Results from other studies have shown that ruminants can drink water with some salinity without negative effects. To date, farmers have also been using brackish Baltic Sea water as a source for their grazing cattle, without observing any obvious health issues. This study is needed to investigate the ability of high-producing dairy cows to drink brackish water with a salinity up to 8 g NaCl per litter of water, which corresponds to the salinity of the Baltic Sea in southern Sweden. In this study, 18 cows in Latin-Square design will be offered drinking water with three different salt concentrations, determined based on the results from the pilot study.
Contact researchers
Anna Jansson, anna.jansson@slu.se, tel.: +4618672106
Sigrid Agenäs, sigrid.agenas@slu.se, tel.: +4618671633
Other participants in the project
Lea Managos, (PhD student, SLU), lea.managos@slu.se, tel.: +46722380077
Cattle: CowCalf 2023 spring
Keeping dairy calves with their dams during the milk feeding period in dairy production is a reoccurring subject gaining increasing interest from both farmers and consumers. However, more knowledge is needed on best-management-practice.
Contact researchers
Sigrid Agenäs, sigrid.agenas@slu.se, tel. +4618671633, +46706973231 Professor at the Department of Animal Nutrition and Management; Management, Ruminants
Hanna Eriksson, hanna.eriksson@slu.se, tel. +4618671949, +46730493911
Claire Wegner (PhD student) claire.wegner@slu.se, tel. +4618672262, +46730293885
Other participants in the project
Gunilla Helmersson (Experiment technician), gunilla.helmersson@slu.se, tel. +4618671605, +46706664379
Cady Wing Yin Chan (student), cyan@stud.slu.se
Cattle: Forest by-products as ruminant feed
This experiment is a part of the FORMAS-funded project Managing forage shortage crises with forest by products. The main objective of the experiment is to evaluate feed intake, digestibility and production in dairy cows if dietary ley silage is partly replaced by either native birch sawdust or by birch sawdust upgraded through a technique known as steam explosion. Steam exploded birch processed by this actual method has in Norwegian laboratory trials reached high digestibility values. This is the first evaluation in a dairy cow experiment.
Contact researchers
Torsten Eriksson, torsten.eriksson@slu.se, tel., +46738098474, +4618671643
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tel., +4618671663, +46722446955
Other participants in the project
Tomas Rondahl, Experiment technician.
Cattle: Induced lameness in dairy cattle
Lameness is a major welfare issue in dairy cattle, resulting in suffering for the cow as well as economic losses for the farmer. Lameness is often visually assessed at walk and can be difficult to detect at an early stage. The most common reason for lameness is claw disorders, which often occurs in both hindlimbs. When two-limb lame, the cow may try to offload both hindlimbs, potentially resulting in an even more challenging lameness to visually assess than a single-limb lameness. The purpose of this project is to understand how cows move during single- and two-limb low-grade lameness.
By measuring the movement pattern with a portable gait analysis system in the home environment of the cows, and by using advanced camera techniques to register movement patterns in the loose-housing system, we can compare measurement values to identify differences in the movement pattern between sound, single- and multi-limb lame cows. We hope that the results from this project will improve early lameness detection by contributing with new knowledge about lameness
Contact researcher
Katrina Ask, katrina.ask@slu.se, tel. +4618672125
Other participants in the project
Maja Söderlind (PhD student, SLU), maja.soderlind@slu.se, tel. +4618672131
Adrien Kroese (PhD student, SLU), adrien.kroese@slu.se, tel. +4618672199
Niclas Högberg (postdoc, SLU), niclas.hogberg@slu.se, tel. +4618672958
Marc Ahlse (Sony Nordic), marc.ahlse@sony.com
Cattle: Using body language to assess emotional states in dairy cows
Currently it is widely accepted that animals can feel pain and suffer, and methodologies assessing the negative welfare have been developed and extensively studied. One cannot say the same in relation to studies on the positive emotions of animals and their related indicators, which is still a challenge. However, body language (e.g. subtle changes in body posture) has been shown to be a potential indicator of their emotional states. We aim to identify indicators of their emotional states using their body language, firstly mapping their body expressions, behaviour and physiological responses (heart rate) under negative and positive controlled conditions in the tie-stall and secondly using these indicators to study their emotional states when experiencing their routine situations in the loose stall (milking, feeding, social interactions and use of mechanical brushes).
As grooming behaviour seems to be linked with positive reward and wellbeing and mechanical brushes becomes more common in loose housing (and cows use them a lot), we aim to evaluate how this form of self-stimulation correlates with other types of grooming behaviour (self-grooming or social grooming) and how the social ranking of the cows in the group and different types of stressful situations correlates with the brush use (e.g. brushes may serve as a "social buffer" in a stressful environment).
We also aim to assess how the production and health parameters relate to the brush use and dairy cows emotional states. To do this we will use the automatically collected (base) data from each cow as well as regular standardised scoring of cleanliness, lameness, injuries etc. We will also take milk samples for later analysis as the treatments may have short term effect milk composition.
Contact
Linda Keeling
Cattle: Effect of incomplete milking on udder health and milk yield on udder quarter level and milk yield on udder quarter level
With automatic milking systems it can happen that one udder quarter will be incompletely milked. This can be caused by the cow kicking off the milking unit or the robotic arm failing to attach the milking unit at the teats. Since the milking process is fully automated no personal is present to reattach the milking unit/teat cup. The udder quarter where the teat cup has fallen off, or where the attachment of the teat-cups have failed will be incompletely milked until the next milking, unless the cow get milking permission within a short time after completed milking. How frequent incomplete milking is and how it will affect the production capacity and udder health is not fully evaluated. Science based results are required for recommendations whether the omitted milked udder quarter should be milked directly after completed milking or if that udder quarter can wait until the next planned milking event.
Contact
Kerstin Svennersten Sjaunja
Cattle: The role of mast cells in bovine mastitis
Mast cells are tissue-resident pro-inflammatory leukocytes recognized as a part of the innate immune system. Mast cells have been shown to influence the course of bacterial infections yielding different outcomes depending on the severity of infection. In severe infections the mast cell has been shown to have a detrimental effect. In other cases it has a protective function.
Mastitis – inflammation of the mammary tissue – is globally the most common disease amongst dairy cows. All forms of the disease incur economic losses in terms of reduced milk yields and treatment costs. The clinical form of the disease in particular impinges the health and welfare of the cow. Mastitis is often the result of a bacterial infection, commonly involving species such as Escherichia coli and Staphylococcus aureus. Our current knowledge of the immunological aspect of mastitis is limited and the putative role of mast cells in this type of disease has not previously been investigated. The goal of this experiment is to determine whether or not the mast cell is involved in the immune reaction to bacterial bovine mastitis. We expect that a deeper understanding of the mast cells role in bacterial mastitis could lead to improvements in diagnostics and treatment. For example, the presence of mast cell inflammatory mediators in the blood of a mastitis afflicted cow could be used as a diagnostic criterion. Similarly, drugs used to counteract the effect of harmful mast cell associated mediators could be brought into use as a mastitis treatment. Alternatively, mast cell components shown to have a protective effect could be used in treatment of mastitis.
Contact
Emma Ternman, emma.ternman@slu.se, +46 (0)18-67 16 18
Cattle: Physiological effects of dairy cow´s usage of mechanical brushes: The effect on plasma oxytocin and plasma cortisol levels, behaviour, immunology, heart rate and heart rate variability
Good welfare can be seen as the possibility to experience positive affective states and not only the lack of poor welfare. Interest in investigating positive emotions in animals has grown lately. There is a need to identify reliable and feasible indicators of positive emotions in animals and grooming behaviour has been indicated as a potential candidate. As the supply of mechanical brushes for dairy cows in loose housing systems is increasing combined with the fact that they are highly used by the majority of the cows, mechanical brush usage become a key component of grooming behaviour to be addressed on farm level.
In this project we will investigate how the use of mechanical brushes interacts with stress at an individual level. More specifically, we plan to assess if the use of mechanical brushes has a buffering effect toward stress and also if its usage can have a calming effect after being exposed to a stressor. These emotional manipulations will be assessed by behavioural, physiological and immunological parameters. Blood samples and heart rate measurements will be taken before, during and after the brush use, in an experimental design testing the exposure to a stressor before and after the brush use.
Contact
Emma Ternman, emma.ternman@slu.se, +46 (0)18-67 16 18
Cattle: Dark vision in dairy calves
According to the Swedish animal welfare legislation lighting during darkness hours is required, but the legislation does not specify minimum or maximum light intensity. Calves and growing cattle, just as lactating animals, benefit from long days with relatively high light intensity, the recommendation is 16 hours light with a minimum of 180 lux. This will enhance growth rate and milk production but in our previous studies we have seen that cows’ activity is changed when exposed to 24 hours of light and that they seem to rest less. For this reason in addition to the environmental aspect of reduced energy consumption, we believe it is important to lower the light intensity during part of the 24-hour period.
Our previous studies have provided us with understanding of the effect of different light intensities and light colours on cow behaviour, we know that they can move around without problem in low light intensities and low light intensities do not reduce their activity at night. However, it has still not been studied how calves react on darkness and this project therefore aims to study whether the calves’ movement pattern change with different light intensities.
Contact
Emma Ternman, emma.ternman@slu.se, +46 (0)18-67 16 18
Cattle: Total mixed ration - competitive feeding system on organic farms with automatic milking?
Farms with automatic milking (AM) have steadily increased in Sweden over the last years and the organic farmers are no exception in this development. One of the most important factors that contribute to maintaining a high production level in AM is well-functioning cow traffic and frequent visits to the milking unit. Low milking frequencies may affect udder health negatively and a common opinion is that it also results in lower milk yield. However, there are studies showing that the relationships are unclear and the causes multifactorial.
In order to achieve a high production level, farmers are often advised not to feed silage or a mixed ration of high nutritional value at the feed bunk, because it is said to lower the cows’ motivation to visit the milking unit. It is not unusual that straw is mixed into the feed in order to reduce the energy content of the mix. Nevertheless, it must be considered a limitation for the production to not use high nutritional feeds when most farmers’ strive to harvest the crop at the optimum stage of development. Scientific literature is scarce on how the feed concentration in a total mixed ration affects milking frequencies and milk yield in AM systems. Hence, the aim of this project is to evaluate these variables when the cows are fed mixed ration versus fed silage and concentrate separately in three different cow traffic systems.
Cattle: Do milk fat have an inhibiting effect on milk synthesis? If so - how could this be used in practice?
2015-11-09 – 2015-12-22
The prerequisite for sustainable dairy production is persistent lactation and high yield. The trend in dairy production is fewer but bigger herds with increasing level of automation, like automatic milking (AM). To increase the efficiency in AM, automatic cluster take off can be done at high milk flow levels and with reduced pre-stimulation, which might have negative impact on udder emptying. In AM each udder quarter is milked separately. However, the knowledge about optimal use of AM, for instance with quarter milking and how the routines influence udder emptying and production, is insufficient. The aim with the project is to evaluate how pre-stimulation and take off level, in combination, shall be practiced for efficient milking in sustainable production. With this new knowledge routines can be developed for better use of AM, optimal milk extraction and better economy.
Contact
Emma Ternman, Emma.Ternman@slu.se, +46 (0)18-67 1618
Sigrid Agenäs, Sigrid.Agenas@slu.se, +46 (0)18-67 1633
Christine Hultén, cehn0001@stud.slu.se, +46 (0)76 868 49 99
Maria Tegevall, mall0002@stud.slu.se, +46 (0)73504 41 20
Cattle: Fortune part 2: Change-over trial with large roughage allowances and byproduct based concentrates
Dairy cows can as all ruminants transform fibrous feed non-edible for humans (e.g. forage and different by-products) into high valuable protein as milk and meat. Today cows are fed substantial amounts of cereal grain and pulse, which instead could be eaten by humans directly. The increasing global demand for human food is contributing to the growing competition of grain cereals and protein-rich products as e.g. soy between humans and production animals and it is assumed to increase. When cereals and other crop are processed into human food or bio fule, then also by-products suitable for dairy cow feed are produced.
The aim with the study is to investigate the effects of a diet completely based on large amount of forage and by-products have on dairy cows production. We expect that these systems will be contribute to a more sustainable milk production, both economically and environmentally.
Contact
Johanna Karlsson
johanna.karlsson@slu.se
Telefon: 018-671256, 072-3410634
Kjell Holtenius
kjell.holtenius@slu.se
018-671629
Rolf Spörndly
rolf.sporndly@slu.se
018-671992, 070-5672189
Mikaela Patel
mikaela.patel@slu.se
018-671013
Filippa Larsson
fila0001@stud.slu.se
Cattle: Pair keeping of calves in calf huts outdoors – impact on growth and suckling behaviour
The use of calf huts outdoors for keeping calves has expanded in recent years and so has the interest in how to increace weight gain and maintain a good health in this environmeant. Today most calves are held separately in the huts even though it is allowed with pair holding. Some of the reasons for this is to maintain a low disease flow between the calves, a good feed intake and also to reduce the risk of the calves suckling on each other. Feeding of milk is usually done with teat buckets two times per day but the common feeding routines do not always satisfy calves need for suckling, with calves showing redirected suckling behaviours as a consequence.
In this study we will look at how weight gain, health and redirected suckling behaviours are affected by keeping calves in pairs versus keeping single calves in calf huts. We are interested in if a good feeding routine for milk in combination with keeping calves in pairs will increase growth and decrease the occurrence of redirected suckling behaviours. Factors will be assessed with behavioural and physiological parameters. Weight measurements will be done when the calves are moved to the calf huts, during the trial and at weaning. Behavioural observations will be done continuously during the trial.
Contact
Lena Lidfors
Phone: +46 (0)51167215; 0703468032
Therese Alvegard
Cattle: Forage based diet to 100 dairy cows in early lactation
Cows are forage eaters, but are today fed with substantial amounts of concentrate based on cereals and pulse (beans etc). Cereals and pulse could instead feed humans directly. The ability to consume forage varies a lot between individual cows. Some of that variation in forage consumption can be explained by genetics.
The purpose of this study is to identify the cows that are best and worse regarding forage consumption, so that we can follow these extremes more closely during next full lactation. This so that we in the future can breed on dairy cows that have a high ability to consume forage which would lead to a lower need of using human-edibles as feed for ruminants at the same time as maintaining high milk yields. This would both increase profitability and decrease the environmental impact of dairy production.
Contact
Johanna Karlsson
johanna.karlsson@slu.se
0723410634
Mikaela Patel
mikaela.patel@slu.se
018-671013
Kjell Holteinus
kjell.holtenius@slu.se
Cattle: Prolific – multidisciplinary study for robust and sustainable improvement of dairy cow fertility
Metabolism and reproductive disorders are gaining importance in parallel with intensifying milk production, in high-producing dairy cows. Genetic progress in conjunction with diet and good herd management helped to increase milk production. It is noteworthy that during the last five decades the number of farms and cows in Sweden has decreased while milk production has actually increased. Looking at the exact numbers and figures we can see that the average yearly milk yield for Swedish red in 1965 was 4833kg while the average milk yield in 2011 was more than 9000kg.
Comparing milk production during the last 50 years with the calving interval you notice that while milk production is getting higher calving intervals are getting longer. It is crucial in order to have a stable and high herd fertility to have an optimal calving interval resulting in fewer inseminations and lower risk for the animal to be culled. During early lactation high producing milk cows are exposed to negative energy balance as the intake food cannot provide the necessary amount of the needed energy which is required for milk production and body needs. The aim of our study is to identify and improve breeding strategies and sustainable management practices in order to optimize cow fertility and robustness.
Contact
Theodoros Ntallaris
Patrice Humblot
Renée Båge
Cattle: Estimation of energy balance in dairy cows using an automatic body condition scoring camera
The energy balance (EB) of dairy cows has impact on animal health, fertility and feed economy. Cows mobilise body reserves in early lactation to support the energy demand from the increasing milk production. Cows that come into critically low EB are at higher risk for health problems and poor fertility. This leads to increasing costs for the farmer in terms of higher culling rates, lower production etc. Efficient routines for early detection of cows with critically low EB are lacking today. Traditionally, manual body condition scoring (BCS) is used for finding cows at high risk but this method is subjective and labor-intensive. With the use of new camera based technique it is now possible to automatically monitor BCS in an objective way which create new possibilities to detect changes in BCS related to energy balance.
The aim of this study is to develop mathematical models to estimate the EB of dairy cows with data from an automatic BCS system. In the study we will gather information from the cows feed consumption, milk production etc. to calculate the EB. Models to estimate the EB with data from the BCS system will be developed by different calculation methods.
Contact
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, +46 (0)18-67 16 63, +46 (0)72-244 69 55
Majbritt Felleki, majbritt.felleki@slu.se, +46 (0)18-67 26 53, +46 (0)72-549 58 26
Other participants in the project
Britta Skottheim, bask0001@stud.slu.se, +46 (0)70-344 53 33
Cattle: Total mixed ration – competitive feeding system on organic farms with automatic milking?
Part 3 – "Milk first" cow traffic
Farms with automatic milking (AM) have steadily increased in Sweden over the last years and the organic farmers are no exception in this development. One of the most important factors that contribute to maintaining a high production level in AM is well-functioning cow traffic and frequent visits to the milking unit. Low milking frequencies may affect udder health negatively and a common opinion is that it also results in lower milk yield. However, there are studies showing that the relationships are unclear and the causes multifactorial. In order to achieve a high production level, farmers are often advised not to feed silage or a mixed ration of high nutritional value at the feed bunk, because it is said to lower the cows' motivation to visit the milking unit. It is not unusual that straw is mixed into the feed in order to reduce the energy content of the mix. Nevertheless, it must be considered a limitation for the production to not use high nutritional feeds when most farmers' strive to harvest the crop at the optimum stage of development. Scientific literature is scarce on how the feed concentration in a total mixed ration affects milking frequencies and milk yield in AM systems. Hence, the aim of this project is to evaluate these variables when the cows are fed mixed ration versus fed silage and concentrate separately in three different cow traffic systems.
Contact
Mikaela Patel
mikaela.patel@slu.se
018-671013
Eva Spörndly
eva.sporndly@slu.se
Cattle: Oesophageal Tube (OT), suckling and bottle colostrum feeding
New born calves have insufficient immunity to fight disease and rely on the transfer of passive immunity, via ingestion of maternal immunoglobulins (IG) present in the colostrum soon after birth, to fight infections. The time of first colostrum feeding, amount of IGs in colostrum and the volume of colostrum consumed all influence the transfer of passive immunity. For these reasons, it is becoming a common practice in dairy farms (especially in North America) to feed colostrum via oesophageal tube (OT) as a way to ensure a good transfer of passive immunity in dairy calves, and now this practice is being promoted in Sweden.
However, the effects of OT feeding on transfer of passive immunity and the long term consequences for health and welfare of the calves have not been studied in detail and in an holistic way that assess not only immunity of the calves but also their welfare. For this reason, the aim of this study is to investigate the effects of OT vs suckling vs bottle feeding at birth on the transfer of passive immunity, physiological, endocrine and behavioural response to the three feeding methods, growth, health and sleep patterns (as a welfare measure) in dairy calves. Another aim is to study the development of gut microbiota, over the first 14 days of calf life, in relation to the feeding treatments.
Contact
Carlos E. Hernandez
Cattle: Osmolality study; Evaluation of animal welfare indicators for dairy cows, with regards to thermic comfort and dehydration
This study aims to develop and produce methods to assess thermal comfort and the degree of dehydration in individual cows, ie, the degree to which a cow ingests enough water for their milk and other bodily functions. The studied methods will be evaluated to see if they can be used in the official control.
Dairy cows need to drink a lot of water for their milk, moreover, they have a great need to get enough water to compensate the second fluid losses (urine, faeces and evaporation). The official animal welfare control controls that feeding and water systems are designed, dimensioned and positioned so as to allow a peaceful and natural intake of food and water and that the requirements for access to water and water quality are met. Today there is no reliable method to determine if the animals get enough water.
The following questions will be answered:
1) Can measurements of skin temperature, fur moisture, respiratory frequency, or shivering be used as animal-based indicators of deviations from animal welfare?
2) Could individual cow milk osmolality be used as an animal-based indicator of dehydration as a complement to the resource-based measurement to assess the degree of dehydration?
3) Can osmolality and/or urea in the urine detect if the cow is dehydrated?
Contact
Birgitta Staaf Larsson
Birgitta.Staaf.Larsson@slu.se
Cattle: Buffering salts for dairy cows
Dairy cows produce large amounts of organic acids during fermentation of feed in the rumen. As a result rumen pH varies over time with a decreasing trend from the morning feeding and throughout the day and an increase during the night, when intake declines and rumination dominates. A low rumen pH might lead to depressed digestion and a condition called sub-acute rumen acidosis (SARA). SARA is associated with diseases, e.g. lameness, and depressed feed intake causing farmers considerable economic losses. A way to prevent low rumen pH is to add buffering salts to the cow diet. Sodium bicarbonate and calcium carbonate have traditionally been used as buffers but the effect on rumen pH has been variable in controlled studies. Calcified seaweed consists of the skeletal remains of dead algea that produce calcium carbonate. There are indications that calcified seaweed has a greater potential then traditional buffer salts in preventing low rumen pH. However, there are few evaluations on producing dairy cows and no one has looked at the effect on digestibility, the key determinant for feed utilization. The aim of this study is to evaluate the effect of dietary buffering agents fed to dairy cows on rumen pH, digestion and milk production.
Contact
Bengt-Ove Rustas, Bengt-Ove.Rustas@slu.se, +46 18-67 16 63
Cattle: The role of mast cells in bovine mastitis
Mast cells are tissue-resident pro-inflammatory leukocytes recognized as a part of the innate immune system. Mast cells have been shown to influence the course of bacterial infections yielding different outcomes depending on the severity of infection. In severe infections the mast cell has been shown to have a detrimental effect. In other cases it has a protective function. Mastitis – inflammation of the mammary tissue – is globally the most common disease amongst dairy cows. All forms of the disease incur economic losses in terms of reduced milk yields and treatment costs. The clinical form of the disease in particular impinges the health and welfare of the cow. Mastitis is often the result of a bacterial infection, commonly involving species such as Escherichia coli and Staphylococcus aureus. Our current knowledge of the immunological aspect of mastitis is limited and the putative role of mast cells in this type of disease has not previously been investigated. The goal of this experiment is to determine whether or not the mast cell is involved in the immune reaction to bacterial bovine mastitis. We expect that a deeper understanding of the mast cells role in bacterial mastitis could lead to improvements in diagnostics and treatment.
Contact
Gunnar Pejler (supervisor), gunnar.pejler@slu.se, +46 (0)18 - 471 45 71
Carl-Fredrik Johnzon (PhD student), carl.fredrik.johnzon@slu.se, +46 (0)18 – 67 21 50
Other participants in the project
Josef Dahlberg (sampling), josef.dahlberg@slu.se, +46 (0)18 – 67 16 86
Cattle: Evaluation of the marker method for measuring feed passage rate
Project starts: 18th of december, 2017
The purpose of this study is to evaluate the marker method for measuring feed passage rate. The evaluation will be based on a comparison of two methods; marker in feed and emptying rumen on four fistulated cows. The overall purpose of this study is to reduce the use of human edible food such as wheat, oats and soya as feed for cows. Today, cows in Sweden are often fed with 50% concentrates (cereals, beans, peas, etc.). We want to reduce the grain based feed by feeding a lot of rough fodder such as silage of grass and clover and small amounts of feed based by-products, focusing on maintaining a high milk production. We also aim to breed for cows that are better adapted to eat a lot of coarse fodder and which at the same time both milk well and feel good. Before we can breed cows with better feed utilization, we want to find out what different parameters affect and influence to reduce the risk of losing efficiency in milk production.
Contact
Rebecca Danielsson, rebecca.danielsson@slu.se phone: +46 (0)18 67 16 28
Other participants in the project
Cecilia Kronqvist, cecilia.kronqvist@slu.se
Maria Åkerlind, maria.akerlind@slu.se
Maria Eklund, student, mand006@stud.slu.se
Cattle: Free cow traffic in an automatic milking rotary parlour (DeLaval AMR)
Project starts 16th of January, 2018 - 5th of June, 2018
Free cow traffic and automatic milking have been applied in conventional milk production with automatic milking stations (AMS) in Sweden for almost 20 years. By automating a milking rotary (AMR), DeLaval has scaled up the automatic milking to fit herds of 500-700 cows. There are a dozen of AMR in the world, but only Lövsta is built to study how this system works with free traffic in in-door environment. From facilities in eg Tasmania, we know that free cow traffic works under grazing conditions. The aim of the project is to study the behavior of animals, production aspects, technical solutions, the operation of traffic systems and the work load of the staff in a series of intensive studies, simulating free traffic in a larger herd, using 120 cows and three available milking periods (windows) per day.
Contact
Jan Olofsson, jan.olofsson@slu.se, Phone: +46 (0)18-67 16 36, +46 70-371 4406
Other participants in the project
Gunilla Helmersson, trial engineer, phone: +46 70-666 4379
Elin Rarcovich, student
Ulrica Robertsson, student
Cattel: Bovine RS virus
2016-01-01 – 2018-02-28
Bovine respiratory syncytial virus (BRSV) is a common cause of respiratory disease in cattle. This virus spreads rapidly between herds and circulates commonly in fattening units in which calves are commingled from several herds. The clinical signs of BRSV are characterized by fever, rapid or abnormal breathing, serous nasal secretions, cough and sometimes subcutaneous emphysema (air
under skin) and anoxia (lack of oxygen) leading to death. The infection is commonly transient but bacteria often grow in damaged lung tissue and these secondary infections are treated with antibiotics.
Our hypothesis is that subclinically infected cows and/or young stock play an important role in the spread of BRSV (besides calves), as is the case for human RSV. Partially immune children and adults spread virus to infants, sometimes without showing clinical signs.
The aim of the study, which constitutes a part of an EU-project (H2020 633184-2, SAPHIR), is to generate knowledge about the immunity against BRSV. Through better understanding we might in the future be able to identify age categories of animals that should be vaccinated in order to stop virus spread within and between herds. This will concern herds in which safe biosecurity measures cannot be applied, until the risk for virus introduction has been reduced. Immune parameters in nasal secretions, tears, salivia and blood will be studied repeatedly from the same individual animals in several herds during two years. Immune cells from the same individuals of different age will be used for studies of immune stimulating agens (adjuvants), in vitro, to contribute to fundamental knowledge about the development of immunity, as well as for the development of age-adopted vaccines. To isolate live virus, a bronchoalveolar lavage will be performed on a few individuals upon diagnosed BRSV infection. Costs and production losses and the kinetics of virus shedding as well as genetic factors will be studied during outbreaks.
Contact
Jean-Francois Valarcher, Sara Hägglund E-post: jean-francois.valarcher@slu.se, sara.hagglund@slu.se
Cattle: Roughage intake ability during a full lactation
Climate change, disturbed nitrogen cycles and loss of biodiversity are among the greatest threats for humanity (Rockström et al., 2009). Another severe challenge is to be able to provide food for everyone in the future when the world population is rapidly increasing while we should not increase the area of arable land (FAO, 2009). We aim at lowering the negative environmental effects of milk production and at the same time increase its positive effects. By feeding more forage and excluding human edible products as cereal grain and beans from the cows diet the net food production can increase (Ertl et al., 2016) at the same time as ecosystem services as carbon sequensation and increased biodiversity is promoted (Knudsen & Hermansen, 2015). The cows forage intake capacity and production of the greenhouse gas methane varies a lot between individuals. The variation depends on a number of factors, as the cows genes, rumen microbiota and passage rate. The aim is to better understand the mechanisms regulating forage intake capacity and methane production, and investigate if it is possible to breed for cows with high forage intake capacity and low methane production. We will also study if it is possible to decrease the nutrient leakage from milk production by decreasing total crude protein (nitrogen) content in the cow diet and instead add rumen protected amino acids in the small by-product based concentrate ration.
Contact
Johanna Karlsson,Johanna.Karlsson@slu.se, +46 (0)723410634
Cattle: Field experiments 2017
Grazing systems for dairy cattle has the potential to be resource efficient for the farmer. However, increased herd sizes can cause major problems with trampling damages on soil leading to clawproblems and dirty udders, which costs working time for cleaning and risk of deteriorated animal health. Farmers ask for durable pasture swards and cost efficient investments. The aim of the project is to develop technical and agronomic solutions for long-term pasture management with a large dairy herd. The objectives are: 1) evaluate four seed mixtures with regard to production and resilience to trampling by measuring vegetation cover, botanical composition, production potential and feed value. 2) evaluate two materials used to protect areas exposed to a high degree of trampling in relation to investment costs. This is a continuation of the field experiments that started 2012.
Contact
Eva Salomon (JTI), eva.salomon@jti.se, Telephone: +46 (0)10-516 69 61, +46 (0)70-595 00 23
Other participants in the project
Martin Sundberg (Part 2), martin.sundberg@jti.se, Telepone: +46 (0)10-516 69 24, Mobile +46 (0)70-370 86 31
Nilla Nilsdotter-Linde (Part 1), nilla.nilsdotter-linde@slu.se, Telephone: +46 (0)18 67 14 31, Mobile: +46 (0)70 662 74 05
Marianne Tersmeden (Part 1 and Part 2), marianne.tersmeden@JTI.se, Mobile: +46 (0)70-952 82 73
Eva Spörndly (Part 1), eva.sporndly@slu.se,Telephone: +46 (0)18 67 16 32, Mobile +46 (0)70-560 979
Cattle: Total mixed ration (TMR) - does it improve animal welfare?
Total mixed ration (TMR) feeding is used to a large extent in the dairy production. It is beneficial for the cow as the forage and the concentrate is mixed together, resulting in a more stable rumen environment compared to when concentrate is fed separately. However, the cows might sort the diet, resulting in some cows consuming high levels of starch-rich concentrate and other cows experiencing difficulties with fulfilling their energy requirements with the feed that is left. The aim of this project is to decrease sorting of the diet by prolonged mixing and addition of water, and to study how this will affect the behavior, intake, production, and rumen health of the cows.
Contact
Mikaela Patel, mikaela.patel@slu.se, phone: +46 (0)18 - 67 10 13
Researcher at the Department of Animal Nutrition and Management
Cecilia Kronqvist, cecilia.kronqvist@slu.se, phone: +46 (0)18 - 67 16 54
Researcher at the Department of Animal Nutrition and Management
Cattle: Pair keeping of calves in calf huts outdoors – impact on growth and play behaviour (degree project)
Calves are commonly kept individually in outdoor hutches during the first period in their life. It is beneficial both from a financial and animal welfare point of view to optimise this type of housing. Studies have shown that pair-housing calves may affect the calves' behaviour, i.a. social behaviour and play behaviour. It has also been shown that calves have better stress coping abilities if they have been pair-housed. Other studies, focusing on feed consumption and growth have found that pair-housed calves consume more feed and had a less impaired growth rate at weaning than individually housed calves. However, no differences in health parameters have been found between pair-housed and individually housed calves. The objective of this study is to compare play and social behaviour on an arena, as well as growth and milk and concentrate consumption between pair-housed and individually housed dairy calves outdoors. Health will also be considered. This is to test the hypothesis that pair-housed calves have unchanged or improved growth rate, better social skills and unchanged health compared to individually housed calves. Because play is considered to function as an animal welfare indicator I will also examine whether pair-housing affects welfare by observing play behaviour on an arena.
Contact
Lena Lidfors, lena.lidfors@slu.se
Other participants in the project
Namn: Ellika Waldau (student), elau0001@stud.slu.se
Cattle: Effects of LED light on activity and production in dairy cows
During the last ten years LED-lights have become available for animal facilities and they are now a common choice when light fixtures are replaced in dairy barns. With LED technology lights with specific wavelengths can be tailor made. This has been well developed for use in greenhouses but there is very limited knowledge about the most suitable wavelengths for animals. The aim of the project is to study effects of LED-light on milk production and activity in dairy cows.
The main hypothesis is that LED light allows maintained cow activity and milk production with less energy used for illumination, and that LED-light makes it possible to apply a dark period during the natural night without decreased milk yield. Two or three trials will be conducted in a light lab at Lövsta, in order to identify suitable wavelengths and light intensities that will be validated in field tests at commercial farms in the finishing phase of the project. The project should result in recommendations for LED-light in dairy barn for decreased energy use at maintained or higher milk production.
Contact researchers
Sofia Lindkvist, sofia.lindkvist@slu.se, tel., +46 (0)18 67 25 82
Björn Ekesten, bjorn.ekesten@slu.se, tel., +46 (0)18 67 18 14
Sigrid Agenäs, sigrid.agenas@slu.se, tel., +46 (0)18 67 16 33 Professor at the Department of Animal Nutrition and Management; Management,Ruminants
Cattle: CowCalf 2019
Keeping dairy calves with their dams during the milk feeding period in dairy production is a reoccurring subject gaining increasing interest from both farmers and consumers. However, more knowledge is needed on best-management-practice. One aim of the study starting summer 2019 is to develop a management system where the cow and calf are kept together, on pasture and in the VMS-free stall during the first 4-5 months of lactation.
Contact researchers
Sigrid Agenäs, sigrid.agenas@slu.se, tel. +46 (0)18 67 16 33, +46 (0)70 556 72 03. Professor at the Department of Animal Nutrition and Management; Management, Ruminants
Hanna Eriksson, hanna.eriksson@slu.se, tel. +46 (0)70 206 92 67. Department of Animal Nutrition and Management; Management Ruminants
Daiana De Oliveira, daiana.oliveira@slu.se, tel. +46 (0)18 67 17 30, 076 903 06 54. Department of Animal Environment and Health; Section of Ethology and Animal Welfare
Other participants in the project
Experiment technician: Gunilla Helmersson, gunilla.helmersson@slu.se, tel. +46 (018) 67 16 05, +46 (0)70 666 43 79
Student on placement from France: Henri Duchaux, duchaux_henri@orange.fr, tel. +33-78-697 65 85
Degree project student: Josefin Molin Björklund, jomo0003@stud.slu.se
Cattle: CowCalf 2020 spring
Keeping dairy calves with their dams during the milk feeding period in dairy production is a reoccurring subject gaining increasing interest from both farmers and consumers. However, more knowledge is needed on best-management-practice. One aim of the study starting spring 2020 is to collect more detailed health data from both cows and calves.
Contact researchers
Sigrid Agenäs, sigrid.agenas@slu.se, tel. +46 (0)18 67 16 33. Professor at the Department of Animal Nutrition and Management; Management, Ruminants
Hanna Eriksson, hanna.eriksson@slu.se, Department of Animal Nutrition and Management; Management Ruminants
Daiana De Oliveira, daiana.oliveira@slu.se, tel. +46 (0)18 67 17 30. Department of Animal Environment and Health; Section of Ethology and Animal Welfare
Josef Dahlberg, josef.dahlberg@slu.se, tel. +4618671686, Department of Animal Nutrition and Management; Management Ruminants
Other participants in the project
Experiment technician: Gunilla Helmersson, gunilla.helmersson@slu.se, tel. +46 (018) 67 16 05
Degree project students:
Johanna Lilja, Carina Tufvesson, Josefin Molin Björklund, Elin Svensson.
Cattle: Processed silage - the "Extruder project"
Jan - april, 2020
The purpose of the project is to increase forage consumption in dairy cows, thereby reducing the need for purchased concentrate feed. Mechanical processing of forage reduces particle size and breaks up plant structures. In the project grass silage will be processed by extrusion, a technique used for pretreatment of biomaterial at biogas plants. The expected result of the processing is increased forage intake and improved utilization of protein through faster rumen passage. The consequence is expected to be a reduced need for purchased protein concentrates.
Contact researchers
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tele +4618671663
Other participants in the project
Research technician: Rainer Nylund, rainer.nylund@slu.se, tele: +4618671635
Cattle: CowCalf 2020 autumn
Keeping dairy calves with their dams during the milk feeding period in dairy production is a reoccurring subject gaining increasing interest from both farmers and consumers. However, more knowledge is needed on best-management-practice. One aim of the study starting autumn 2020 is to collect more detailed health data from both cows and calves.
Contact researchers
Sigrid Agenäs, sigrid.agenas@slu.se, tel. +4618671633. Professor at the Department of Animal Nutrition and Management; Management, Ruminants
Hanna Eriksson, hanna.eriksson@slu.se, tel. +46730493911 Department of Animal Nutrition and Management; Management Ruminants
Other participants in the project
Experiment technician: Gunilla Helmersson, gunilla.helmersson@slu.se, tel. +4618671605
Degree project students:
Rebecka Lindqvist, Erik Backman, Rebekka Bakke
Cattle: Milk urea concentration
The experiment is part of a larger project for facilitating a transition to more homegrown protein feeds in dairy herds. The objective of this certain experiment is to study the changes in milk urea concentration on short term and intermediate time basis when disturbances in protein feeding are simulated. Milk urea is a marker that reflects the protein status of the dairy cow. The experiment should provide guidelines that indicates which magnitude of change in milk urea concentration that indicates error in the concentrate processing chain, requiring action.
Contact researchers
Torsten Eriksson, torsten.eriksson@slu.se, +46 18 67 16 43. Department of Animal Nutrition and Management
Other participants in the project
Rainer Nylund, rainer.nylund@slu.se, +46 18 67 16 35.Department of Animal Nutrition and Management.
Cattle: The body language of dairy calves: Investigating emotions through ear, neck and tail posture
Degree project
Though much progress has recently been made, information regarding the identification and understanding of positive emotions in animals is still lacking. While the avoidance of negative emotions in animals is important for a high quality of welfare, ensuring the presence of positive emotions is equally important. Recent research has begun to explore interactions between positive emotions and various physical observations of dairy cows, such as ear posture.
The aim of this study is to further develop this research through analyzing the relationship between ear, tail and neck postures of dairy cows and positive/negative emotion. Specific predictions regarding links between body posture and emotional states will be made based on previous research.
Contact researcher
Linda Keeling, linda.keeling@slu.se, +46(0)18 67 16 22. Department of Animal Environment and Health
Other participants in the project
Kirste Colleen Mccrea, kimc0001@stud.slu.se, +46 (0)727 14 28 44
Yezica Norling, Yezica.Norling@slu.se, +46 (0)18 67 21 15
Daiana de Oliveira, Daiana.Oliveira@slu.se, 018-67 17 30
Cattle: Processed silage - the "Extruder project"
Jan - april, 2020
The purpose of the project is to increase forage consumption in dairy cows, thereby reducing the need for purchased concentrate feed. Mechanical processing of forage reduces particle size and breaks up plant structures. In the project grass silage will be processed by extrusion, a technique used for pretreatment of biomaterial at biogas plants. The expected result of the processing is increased forage intake and improved utilization of protein through faster rumen passage. The consequence is expected to be a reduced need for purchased protein concentrates.
Contact researchers
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tele +4618671663
Other participants in the project
Research technician: Rainer Nylund, rainer.nylund@slu.se, tele: +4618671635
Cattle: CowCalf 2021 spring
Keeping dairy calves with their dams during the milk feeding period in dairy production is a reoccurring subject gaining increasing interest from both farmers and consumers. However, more knowledge is needed on best-management-practice. One aim of the study starting spring 2021 is to study the difference between weaning the calves at 4 and 8 months of age.
Contact researchers
Sigrid Agenäs, sigrid.agenas@slu.se, tel. +4618671633, +46705567203 Professor at the Department of Animal Nutrition and Management; Management, Ruminants
Other participants in the project
Experiment technician: Gunilla Helmersson, gunilla.helmersson@slu.se, tel. +4618671605
Degree project students and others.
Cattle: Changes in the rumen’s fiber degrading enzyme system when forest by-products are included in the ration.
The main objective of this experiment is to study changes in the rumen’s fiber degrading enzyme system when forest by-products are included in the ration. In addition, standard measurements of intake pattern, digestibility and general rumen metabolism will be performed. The objective of the entire project is to evaluate forest by-products (wood chips and bark, unprocessed or upgraded), as a roughage extender for dairy cows during shortage episodes.
Processed forest by-products were during World War 2 extensively fed to cattle and horses in Sweden. Feeding trials have since then occasionally been performed internationally, most recent as a pilot experiment at NMBU in Norway 2018 where dairy cows quickly adapted to eating 6 kg dry matter aspen sawdust/day. Aspen is the tree species that has displayed the highest digestibility in vitro and when fed to ruminants.
Contact researchers
Torsten Eriksson, torsten.eriksson@slu.se, tel. +4618671643
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tel. +4618671663
Cattle: An obstacle course study - the acitivity of dairy cows during movement in different light environments
During the dark hours, the activity of dairy cows is lower than during daytime. Less activity during night-time could affect the productivity in automatic milking systems. There is a general perception that cows are more likely to suffer from teat injuries in darkness due to stress and fear of darkness. In 2013, an obstacle course study was conducted at Lövsta where the cows’ activity, heart and respiratory rate were registered in four different light intensities and with or without red light. Today, it is possible to measure light with greater precision and to use LED lamps with their own control center to be able to create different light environments. The cows will be trained in the obstacle course in full daylight and then test the obstacle course in different light environments; white, red and blue light. The purpose of the obstacle course study is to investigate the activity of the cows during movement in different light environments.
Contact researcher
Sofia Lindkvist sofia.lindkvist@slu.se tele +4618672582
Department of Animal Nutrition and Management, Management Ruminants
Cattle: Orthopaedic pain in cattle - lameness and pain
Orthopaedic pain, with lameness as the main symptom, is one of the biggest welfare issues in dairy cows around the world, leading to a decrease in milk production, feed intake and fertility. To minimize the pain and improve the prognosis, it is important to detect lameness at an early stage and initiate correct treatment. The purpose of this project is to study the movement patterns in lame cows and describe their pain behaviour and pain face. We measure movement symmetry with small accelerometers mounted on the body, and compare the results with results from healthy cows. Pain behaviour and pain face are recorded on video, described for cows with lameness, and compared to behaviours and facial expressions in healthy cows. With detailed knowledge of how cows adapt their movements during lameness and how they express orthopaedic pain, we hope to be able to identify lameness earlier and assess pain in a more precise way thereby increasing the welfare in dairy cattle.
Contact researchers
Katarina Ask (PhD student, SLU), katarina.ask@slu.se, tel.: +46 (0)18 67 21 25
Marie Rhodin, marie.rohdin@slu.se, tel.: +46 (0)18 67 21 94
Christer Bergsten, christer.bergsten@slu.se, tel.: +46 (0)70 399 33 29
Pia Haubro Andersen, pia.haubro.andersen@slu.se, tel.: +45 313 181 47
Elin Hernlund, elin.hernlund@slu.se, tel.: +46 (0)18 67 21 42
Marij Tijssen (PhD student, Utrecht University), m.tijssen@uu.se, tel.: +31 654 788 348
Cattle: Milk fatty acids – tools to identify cows with increased risk för metabolic diseases and fertility disturbances
The aim of this project is to develop precision tools based on specific milk fatty acids in order to identify cows that have an increased risk to develop metabolic diseases and fertility disturbances. The study will be performed at SLU´s dairy research farms at Lövsta and Röbäcksdalen. We will determine key fatty acids in milk, hormones and metabolites in blood reflecting metabolism and fertility. The goal is to pinpoint milk fatty acids that reflect metabolic and reproductive disturbances in cows. A second study will be performed in 20 large commercial dairy herds. We will have access to milk fatty acid profiles, yield, veterinary treatment and fertility recordings. The ultimate goal of the project is that the farmers should have simple access to tools that will support actions both on individual- and herd level that contribute to sustainable milk production.
Contact researcher
Kjell Holtenius, kjell.holtenius@slu.se, tel. +4618671629, +46701721873
Other participants in the project
Gunilla Helmersson, gunilla.helmersson@slu.se, tel. +4618671605, +46706664379
Cattle: Probiotics to dairy cows
Probiotics are feed supplements containing living microorganisms that are considered to benefit the health of the recipient animal. Microbial supplements have been used in cattle for at least 30 years, mainly to improve growth, milk production or feed efficiency. Probiotics for adult cattle are supplied mainly to improve fiber digestibility and prevent rumen acidosis.
The purpose of the experiment is to evaluate the effect of a probiotic feed supplement on dairy cows' feed utilization and production.
The probiotic supplement we are going to study in this experiment contains spores from bacteria within the bacillus genus. In the experiment, we will study how the added bacteria affect the cows' feed consumption, milk production, feed digestibility and feed efficiency. We will also investigate whether probiotics affect the somatic cell count of milk.
Project starts in September, 2021.
Contact researcher
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tele +4618671663
Researcher at the Department of Animal Nutrition and Management; Feed science
Cattle: Mastit treatment strategies
2021-04 – 2022-12
Inflammation of the udder, or mastitis, is the most common disease in Swedish dairy cows, and it is both painful for the affected animal and leads to loss of milk production and economic consequences for the dairy farmer. Modern techniques in automatic milking systems (milking robots) enable more detailed supervision of animal health and udder health status of dairy cows, compared to manual supervision and test milking once a month. However, we lack knowledge on how to utilize the modern techniques in the best way for the daily work in dairy herds. This pilot study is part of a larger research project on mastitis treatment strategies in Swedish dairy herds with automatic milking systems. The aims of the pilot study are to find out if information collected automatically in the milking robot can be used to evaluate the udder health of dairy cows, and how well that information corresponds to other information on udder health, collected by manual milk samples and test milking results.
Contact researcher
Lisa Ekman, lisa.ekman@slu.se
Cattle: Evaluation of vaccines against bovine respiratory syncytical virus (BRSV)
2023
The aim of this project is to evaluate vaccines against bovine respiratory syncytial virus (BRSV) in young calves with maternally-derived antibodies. These antibodies originate from the first milk of the mother and can protect the calf against disease by binding to pathogens. However, the same antibodies can additionally bind to vaccines and will thereby inhibit the effect of vaccination in young calves. Bovine RSV is very contagious and causes annual outbreaks of respiratory disease in Swedish cattle. A closely related virus, the human RSV, can likewise cause serious disease in humans, mainly in infants and elderly.
While vaccines against BRSV exist for cattle, no vaccine against HRSV is available for humans. This is due to adverse effects of earlier vaccines, a weak immune system in infants and the interference with maternally-derived antibodies. However, a break-through recently occurred in RS-vaccinology. A viral protein (the fusion protein) was stabilised in a form (Pre-F) that induces strong immune responses in humans and better responses than a commercial vaccine in calves with maternal antibodies. In contrast to when using commercial vaccines, the usage of Pre-F enables disease monitoring based on serology, which currently is carried out on a voluntary basis in Sweden. With a Pre-F-based vaccine, infected animals can be differentiated from those non-infected but vaccinated, which allows tracking the virus among herds, with the possibility to warn nearby counties. Within the project, the immune response to candidate vaccines based on different parts of PreF will be evaluated in calves and the calves that will stay in the herd will be followed up throughout their life by blood sampling. If a natural BRSV-infection occurs in the herd during the lifespan of the animals, the clinical and virological protection of the vaccines will be evaluated.
Contact researchers
Jean Francois Valarcher, jean-francois.valarcher@slu.se, tel., +4618671351.
Other participants in the project
Sara Hägglund, sara.hagglund@slu.se, tel., +4618671891.
Cattle: Biomarkers for detection of subacute ruminal acidosis (SARA) in dairy cows
2023
The Swedish dairy industry has made significant improvements in animal welfare, feeding, disease control and herd management. However, diagnosis and prevention of a very common metabolic disorder, subacute ruminal acidosis (SARA), remains a challenge. Even in well-managed dairy herds, 11 to 26% of SARA cases are suspected in cows in early to mid-lactation period, resulting in significant direct and indirect economic losses, and leading to suffering in domesticated cows. SARA lacks clear symptoms, and is difficult to diagnose with existing methods. We propose to fill this gap by identifying metabolites in bio-fluids associated with the onset and progression of SARA using state-of-theart metabolomics techniques and developing a novel paper-based test for early detection. Our goal is to provide a novel detection method for SARA, support cattle welfare, make the dairy production more sustainable and efficient and promote climate-friendly production through optimal feed conversion.
Contact researchers
Horacio Gonda, horacio.gonda@slu.se, tel.: +4618672350
Rebecca Danielsson, Rebecca.danielsson@slu.se, tel.: +4618671628
Other participants in the project
Jean Francois Valarcher, jean-francois.valarcher@slu.se, tel., +4618671351.
Sara Hägglund, sara.hagglund@slu.se, tel., +4618671891.
Bengt-Ove Rustas, bengt-ove.rustas@slu.se, tel.: +46722446955
Torsten Eriksson, Torsten.Eriksson@slu.se, tel.: +4618671643
Maria Åkerlind, maria.akerlind@vxa.se